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There have been no practical experience up to now with using METROGEL-VAGINAL in pregnant patients. Metronidazole crosses the placental barrier and enters the fetal circulation quickly. No fetotoxicity or teratogenicity was noticed when metronidazole was administered orally to pregnant mice at six occasions the advisable human dose (depending on mg/m2); however, in just one tiny examine exactly where the drug was administered intraperitoneally, some intrauterine deaths were noticed. The relationship of those conclusions for the drug is unfamiliar.
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You can find, having said that, no adequate and nicely-managed research in Expecting women. Since animal copy reports are certainly not generally predictive of human response, and because metronidazole is often a carcinogen in rodents, this drug need to be made use of all through pregnancy only if clearly required.
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